Lenovo ThinkSystem Servers with AMD EPYC™ Processors

   Every business is looking for an edge in data and computing infrastructure. The technical requirements, energy demands, and other costs of today’s must-have artificial intelligence (AI) solutions are enormous, so there’s true competitive advantage in right-sizing—and right-powering—your platforms. This is where the long and innovative Lenovo-AMD relationship comes into play: two companies delivering advanced AI processing and server solutions to redefine what’s possible for businesses around the globe.

This text will take a deep-dive into Lenovo servers with AMD processors, exploring how solutions using AMD EPYC™ processors can help you speed your AI transformation from the data center to the edge. We'll cover everything from the features of AMD EPYC™ processors to the advanced Lenovo ThinkSystem servers they power.

When two giants like Lenovo and AMD team up, you know to expect something special. We share a vision for the future of computing built on performance, security, and efficiency. The result? A comprehensive portfolio of Lenovo servers with AMD processors designed to tackle the computing demands of today and tomorrow.

AMD EPYC™ Processors & Lenovo Servers

At the heart of the most powerful AMD-powered Lenovo servers are AMD EPYC™ processors. Recent versions of these processors aren't just an incremental upgrade; they represent a fundamental shift in server architecture. Here’s some of what makes the AMD EPYC™ processor brand such a game-changer:

• Outstanding Performance and Core Density—AMD EPYC™ processors are known for their high core counts. More cores mean more power to run simultaneous applications and processes, which is crucial for virtualization, cloud computing, and database management. In fact, this density allows a single AMD EPYC™-powered server to do the work of multiple older servers, potentially shrinking your footprint and simplifying management.


• Groundbreaking security features—Security is non-negotiable, and AMD EPYC™ processors come with advanced security capabilities built right into the silicon. This includes features that help secure data while it's in use, in transit, and at rest. By encrypting main memory, for example, these processors can help protect against physical attacks and many other, more sophisticated threats.


• Leading Energy Efficiency—Powering a data center is expensive, and energy consumption is a major concern for today’s companies—both in terms of spending and corporate sustainability goals. The efficient architecture of AMD EPYC™ processors delivers exceptional performance-per-watt. So you can get the computing power you need while using (and paying for) less power from the grid.

Lenovo ThinkSystem Servers Powered by AMD

Lenovo's deep portfolio of ThinkSystem servers is widely popular and respected for innovation, scalability, and reliability. When powered by AMD EPYC™ processors, they’re practically an unstoppable force for any workload, including today’s super-demanding, always-on AI applications and services.

ThinkSystem SR645 V3 & SR635 V3: Versatile Workhorses

Lenovo ThinkSystem SR645 V3 and SR635 V3 rack servers are AMD-powered and designed for versatility. Housed in a compact 1U form factor, these servers are perfect for environments where space is at a premium but performance can’t fall short. The SR635 V3 is a single-socket powerhouse ideal for storage-rich workloads, while the dual-socket SR645 V3 excels at managing growing data volume, variety, and velocity with ease. They’re strong choices for cloud, VDI, and data analytics.

ThinkSystem SR665 V3 & SR655 V3: Power Players

When your applications demand maximum performance, the 2U Lenovo ThinkSystem SR665 V3 and SR655 V3 servers step up. These dual-socket AMD-powered servers are built for the most demanding enterprise data center workloads. The SR655 V3, for instance, supports a massive amount of memory and multiple GPUs, making it a perfect platform for high-performance databases and AI. The SR665 V3 delivers the horsepower needed for everything from big data analytics to complex virtualization environments.

ThinkSystem ST45 V3: Enterprise Power for SMBs

Not every business has a sprawling data center. The Lenovo ThinkSystem ST45 V3 tower server brings the power of AMD EPYC™ processors to small and medium-sized businesses (SMBs), remote/branch offices, and other confined environments. It’s a compact, budget-friendly design that delivers enterprise-grade performance and reliability, allowing smaller organizations to scale with confidence—and without needing a dedicated server room.

These are just a few examples of powerful Lenovo ThinkSystem servers with AMD processing. In-stock availability will vary, so if you’re shopping, use the navigation on the left side of this page to view our full line-up of AMD-powered servers.

AI, High Performance Computing & Hyperconverged Infrastructure

AI, high-performance computing (HPC), and hyperconverged infrastructure (HCI) are no longer just for massive research labs. Businesses of all sizes are leveraging these technologies for everything from product development to customer service. Fortunately, the Lenovo AMD “partnership” is at the leading edge of this movement, offering the infrastructure needed to power all of it.

Lenovo & AMD: Driving AI Innovation from Edge-to-Cloud

Whether you're running AI inferencing tasks at the edge or training massive language models in the data center, server solutions from Lenovo and AMD deliver the speed and efficiency required. In particular, the combination of powerful AMD EPYC™ processors and high-performance AMD Instinct™ GPUs creates an incredibly potent platform for AI.

For example, the Lenovo ThinkSystem SR685a V3 is an AI beast, designed to handle the most demanding AI tasks. It can house up to eight GPUs, making it ideal for deep learning, scientific modeling, and advanced rendering workloads across sectors like fintech, energy, research, and more.

Lenovo & AMD: Pushing the Boundaries of HPC

In the world of HPC, every ounce of performance matters. Take the Lenovo ThinkSystem SD665-N V3 Supercomputing Server with AMD EPYC™ processing, for example. It’s engineered for exascale performance and uses Lenovo Neptune liquid cooling technology. [Using liquid to cool the components helps the server run the processors at their peak potential for longer periods, delivering maximum performance while remaining incredibly energy efficient.]

Another key player for HPC workloads is the AMD-powered Lenovo ThinkSystem SR675 V3 server. This versatile system can scale-up from a single-node enterprise deployment to a bigger cluster—a sign of the flexibility of servers from Lenovo and AMD.

Lenovo & AMD: Hyperconverged Infrastructure

Traditional IT infrastructure can be complex and slow to deploy. Hyperconverged Infrastructure (HCI) helps by combining compute, storage, and networking into a single, software-defined solution.

Here are some Lenovo ThinkAgile HCI solutions that offer a fast, scalable, and efficient way to modernize your IT:

• ThinkAgile HX Series—The ThinkAgile HX Series is designed for rapid deployment, so it’s faster than building your own infrastructure. This allows you to focus on your core business instead of IT setup and management chores. With the performance of an AMD EPYC™ server at its core, the HX series provides a powerful and resilient platform for your virtualized applications.


• ThinkAgile MX Series—As more data is generated and processed at the edge, you need infrastructure that can keep up. The ThinkAgile MX Series is optimized for edge AI and hybrid cloud environments. It delivers real-time AI inferencing capabilities where you need them most, enabling smarter, faster decisions on-site.


• ThinkAgile VX Series—For organizations heavily invested in virtualization, the ThinkAgile VX Series offers a turnkey, co-engineered HCI solution. It’s designed for faster deployments and seamless operational management, providing a highly reliable and performant foundation for your virtual machines and applications.

Real-World Success: Lenovo Servers Powered by AMD

The true measure of any technology is the impact it has in the real world. Organizations across multiple industries are using AMD-powered solutions from Lenovo to achieve incredible things.

Creating Mind-Blowing Immersive Experiences

One of the world's most advanced entertainment venues relies on Lenovo ThinkSystem servers powered by AMD EPYC™ processors to generate its mind-blowing visual content. The immense computational power of the ThinkSystem SR655 and SR665 V3 servers allows content creators to bring limitless visual storytelling to life on a massive scale, creating unforgettable immersive experiences for audiences.

Enhancing Safety and Security with AI

In the healthcare sector, a forward-thinking company is using AI to improve patient care. By deploying Lenovo ThinkEdge SE455 V3 servers with AMD EPYC™ processors at the edge, they can perform real-time AI analysis of sensor feeds. This enables caregivers to more quickly identify at-risk patients and respond, providing a new level of proactive care.

Powering Next-Level Motor Racing

A global motor racing series uses a technology center running Lenovo AMD-powered solutions to connect its race series, operations, teams, and broadcasters seamlessly. The system captures over 10,000 data points per second, providing real-time insights that enhance the experience for everyone involved, from the drivers on the track to the fans watching at home.

Advancing Critical Climate Research

A leading institute for climate research is gaining new HPC capabilities to advance its vital work. By using a supercomputer featuring Lenovo ThinkSystem servers powered by AMD EPYC™ processors and cooled by Lenovo Neptune technology, researchers can run more complex simulations faster than ever.

These are just a few examples. From financial news agencies delivering real-time stock data to engineering consultants achieving an estimated five times faster performance on design workloads, the story is the same: Lenovo servers with AMD processing provide the power and reliability needed to innovate and succeed.

The Future is Bright with Lenovo and AMD

Lenovo and AMD continue to push the envelope of what's possible in enterprise computing. With the introduction of new generations of AMD EPYC™ processors, the performance, efficiency, and security capabilities of AMD-powered Lenovo servers are reaching new heights.

These solutions are designed to help you build and operate your enterprise AI infrastructure to meet your goals for performance, security, and sustainability. As AI becomes more integrated into every aspect of business, having an infrastructure that can support it effectively will be the key differentiator between leading and lagging organizations.

Lenovo infrastructure solutions powered by AMD EPYC™ processors offer a clear path to modernizing your IT, accelerating your workloads, and preparing your business for the future. From compact tower servers for small businesses to liquid-cooled HPC systems for massive-scale research, there's an AMD-powered solution from Lenovo that’s ready to tackle your unique challenges.